I think it's because Arixtra is mainly excreted/eliminated by the kidneys ... so if your kidneys are not working Arixtra won't be eliminated properly and would accumulate in your body ... causing all sorts of adverse effects.
Elimination: In individuals with normal kidney function, fondaparinux is eliminated in urine mainly as unchanged drug. In healthy individuals up to 75 years of age, up to 77% of a single subcutaneous or intravenous fondaparinux dose is eliminated in urine as unchanged drug in 72 hours. The elimination half-life is 17 to 21 hours.
- Arixtra Information for Consumers
- Arixtra Information for Healthcare Professionals (includes dosage details)
- Side Effects of Arixtra (detailed)
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