I was diagnosed with RA in 2009. I was started on prednisone, methotrexate, plaquenil, azulfidine, and folic acid. The prednisone was the worst! I think I was on prednisone for about 6 months. I have noticed that almost everyone is on prednisone daily, and am wondering why? Although I don't like taking the meds, I now know that I will probably be taking them for the rest of my life. My goal is to stay off of prednisone, but I realize that I may need to take it for a severe exacerbation. For the people who take prednisone on a regular basis are you taking it because of the pain? I am glad I am off of it, and will do everything I can to stay off.