Both clobetasol and halobetasol are classed as superpotent topical corticosteroid medicines. Many studies have been done but none of them have showen tha one is better than the other. Long term use shows that they both have the same sort of outcome and one is not superior to the other.
Both medications are within the same class "Super Potent" and are of similar structure - glucocorticoid steroids.
However, there is some research that indicates a slight but statistically significant benefit to using halobetasol over clobetasol. In a double-blind multi-center study remission rates were higher and response times were faster for those using halobetasol versus those using clobetasol.
I have used both for treating my own plaque psoriasis. I find that they are of equal benefit and usually use one for a period of time, begin to develop some resistance then switch to the other. This "cycling" occurs every six to 12 months.
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