How long it takes for a medicine to be totally cleared from your system depends on it's elimination half life. It takes approximately five and a half (5.5), elimination half lives for the drug to be cleared.
For methotrexate the elimination half life is dose dependent, with the maximum being 15 hours. Therefore it would take 82.5 hours (15 x 5.5) for it to be totally out of your system.
That is about 3.5 days. It would not be advisable to breastfeed your baby any sooner then that, unless you are able to get blood tests done to confirm all the methotrexate has been eliminated.
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