My husband, 50 years old, is starting 800 mg Votrient later this week. We have read a lot of published literature, but would love some feedback from people that are taking it. How long does it take before the side effects kick in? What have you found to be the most difficult to manage side effect and how are you dealing with it? Any and all links to information are greatly appreciated. I tried to post this question last night, but appear to have done something wrong, as it did not appear this morning. Sorry if it is a duplicate. Thanks in advance for your support!