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What's the order of degradation of bisacodyl ?

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Marvell 27 Dec 2010

I don't know if the information below answers your question totally ... but this is what I could find.

Bisacodyl - Clinical Pharmacology

Mechanism of Action HalfLytely and Bisacodyl Tablets Bowel Prep Kit induces diarrhea which cleanses the colon. 12.2 Pharmacodynamics Bisacodyl, a stimulant laxative, is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; (BHPM)] that acts directly on the colonic mucosa to produce colonic peristalsis. 12.3 Pharmacokinetics The osmotic activity of HalfLytely solution results in no net absorption or excretion of ions or water.

MECHANISM OF ACTION

HalfLytely and Bisacodyl Tablets Bowel Prep Kit induces diarrhea which cleanses the colon.

PHARMACODYNAMICS

Bisacodyl, a stimulant laxative, is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; (BHPM)] that acts directly on the colonic mucosa to produce colonic peristalsis.

PHARMACOKINETICS

The osmotic activity of HalfLytely solution results in no net absorption or excretion of ions or water.

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