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What will happen if I drink an excess of alcohol while I take Methotrexate?

Responses (1)

LaurieShay 5 Jun 2011

Hey cindylou,

Not a good combination. The methodrexate is already causing your liver to work hard and the alcohol just makes it worse. The interaction between these two substances is as follows:

methotrexate ↔ ethanol

Applies to: methotrexate, Alcohol (contained in alcoholic beverages) (ethanol)

GENERALLY AVOID: Coadministration of methotrexate with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Methotrexate, especially at higher doses or with prolonged treatment, has been associated with hepatotoxicity including acute hepatitis, chronic fibrosis, necrosis, cirrhosis, and liver enzyme elevations.

MANAGEMENT: The use of methotrexate in combination with other potentially hepatotoxic agents (e.g., acetaminophen; alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; endothelin receptor antagonists; interferons; nucleoside reverse transcriptase inhibitors; retinoids; thiazolidinediones; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, HMG-CoA reductase inhibitors, and niacin; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice) is generally not recommended unless the potential benefit outweighs the risk. Patients treated with methotrexate should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, light-colored stools, and jaundice. Baseline and regular monitoring of hepatic function is recommended.

So I don't recommend excessive drinking while taking methotrexate as it may permanently damage your liver.

Best wishes,


Inactive 5 Jun 2011

Amen Laurie, my husband is on methatrexate for RA and he has to have his liver ckecked very often, they have him on folic acid too. It is very important you do not drink. free discount card

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