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What is the proper dosage for adults and children for Triamterene/HCTZ?

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suzanne66 26 Aug 2009

The following are the fda recommended dosage details for Triamterene and Hydrochlorothiazide from:

"..Note: 37.5 mg/25 mg=37.5 mg triamterene and 25 mg hydrochlorothiazide
75 mg/50 mg=75 mg triamterene and 50 mg hydrochlorothiazide

The usual dosage of Triamterene and Hydrochlorothiazide as a tablet is 37.5 mg/25 mg or 75 mg/50 mg daily, given as a single dose, with appropriate monitoring of serum potassium (seeWARNINGS). There is no experience with the use of more than 75 mg/50 mg daily of Triamterene and Hydrochlorothiazide. Clinical experience with the administration of 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide twice daily (in divided doses rather than as a single dose) suggests an increased risk of electrolyte imbalance and renal dysfunction.

Patients receiving 50 mg of hydrochlorothiazide who become hypokalemia may be transferred to this 75 mg/ 50 mg product directly. Patients receiving 25 mg hydrochlorothiazide who become hypokalemic may be transferred to a 37.5 mg/25 mg product directly.

In patients requiring hydrochlorothiazide therapy and in whom hypokalemia cannot be risked, therapy may be initiated with 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide. If an optimal blood pressure response is not obtained with 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide, then the dose should be increased to 75 mg/ 50 mg daily as a single dose. If blood pressure still is not controlled, another antihypertensive agent may be added (seePRECAUTIONS, Drug Interactions).

Clinical studies have shown that patients taking less bioavailable formulations of Triamterene and Hydrochlorothiazide in daily doses of 25 to 50 mg hydrochlorothiazide and 50 to 100 mg of triamterene may be safely changed to 37.5 mg/25 mg of Triamterene and Hydrochlorothiazide daily. All patients changed from less bioavailable formulations to this product should be monitored clinically and for serum potassium after the transfer."

I could find no specific dosage details for children.

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