After 20 years of taking all approved SSRIs, SSNRs, and tricyclic antidepressants, my doctor has prescribed Parnate. I am currently taking 60 mg/day, and I have noticed some improvement, but not significant. I read an article that some patients require 90+mg/day to achieve efficacy. One reviewer below noted 160 mg/day of Parnate as his/her effective dose. All input is appreciated.