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What is the minium and maximum dosage of cisplatin?

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Marvell 5 Feb 2010

This is the Dosing Information for Cisplatin

Usual Adult Dose for Testicular Cancer:

20 mg/m2 intravenously once a day for 5 days per cycle (in combination with other antineoplastic drugs)

Usual Adult Dose for Ovarian Cancer:

75 to 100 mg/m2 intravenously once every 4 weeks (in combination with cyclophosphamide for the treatment of metastatic ovarian cancer).

Alternatively, 100 mg/m2 intravenously once every 4 weeks may be administered (as a single agent for the treatment of metastatic ovarian cancer).

If the ovarian cancer remains confined to the peritoneal cavity, the following regimens may be used:

60 to 90 mg/m2 in 2 liters of 0.9% sodium chloride solution or lactated Ringer's injection intraperitoneally once.

Alternatively, 90 to 270 mg/m2 in 2 liters of 0.9% sodium chloride solution or lactated Ringer's injection intraperitoneally once may be administered (to be given with intravenous sodium thiosulfate to reduce the risk of nephrotoxicity associated with this relatively high dose).

Usual Adult Dose for Bladder Cancer:

50 to 70 mg/m2 intravenously once every 3 to 4 weeks (as a single agent for the treatment of advanced bladder cancer in patients WITHOUT history of extensive X-radiation or chemotherapy).

Alternatively, 50 mg/m2 intravenously over 6 to 8 hours every 4 weeks may be administered (as a single agent for the treatment of advanced bladder cancer in patients WITH history of extensive X-radiation or chemotherapy)

Usual Adult Dose for Neuroblastoma:

60 to 100 mg/m2 once every 3 to 4 weeks

Usual Adult Dose for Osteogenic Sarcoma:

60 to 100 mg/m2 once every 3 to 4 weeks

Usual Adult Dose for Brain/Intracranial Tumor:

60 mg/m2 once a day for two consecutive days every 3 to 4 weeks

Usual Adult Dose for Bone Marrow Transplantation:

Continuous infusion: High Dose: 55 mg/m2/day for 72 hours (Total Dose = 165 mg/m2)

Usual Adult Dose for Blood Cell Transplantation:

Continuous infusion: High Dose: 55 mg/m2/day for 72 hours (Total Dose = 165 mg/m2)

Usual Adult Dose for Non-Small Cell Lung Cancer:

60 to 100 mg/m2 intravenously on day one every 21 days (in combination with other antineoplastic drugs)

Usual Adult Dose for Cervical Cancer:

(In combination with radiation therapy)
40 mg/m2 IV weekly
Maximum dose: 70 mg/week
Cisplatin is given 4 hours before radiation therapy on weeks 1 through 6

(In combination with paclitaxel)
75 mg/m2 IV on day 2
The cycle is repeated every 21 days.

(In combination with other chemotherapeutic agents as a part of the BIP regimen)
50 mg/m2 IV on day 2
The cycle is repeated every 21 days.

(In combination with other chemotherapeutic agents as a part of various regimens)
50 to 200 mg/m2 IV on day 1

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