What is the mechanism of misoprostal tablets in relation to postpatum bleeding
I got the information below from the link below. Mechanism of action of misoprostal in postpartum bleeding is not established.
Misoprostol, a prostaglandin E1 analog, is used orally for the prevention and treatment of gastric/duodenal ulcer caused by the use of nonsteroidal anti-inflammatory agents (NSAIDs). Its safety for this indication has been established over several years. Oral absorption is rapid and its side effects are usually mild and infrequent.
Misoprostol has been shown to be a potent uterotonic agent selectively binding to EP2 or EP3 prostanoid receptors. Its effect on the early pregnant uterus has been shown to be rapid. It has been investigated in the induction of labor, cervical priming, and induction of abortion, either alone or in combination with mifepristone.
Misoprostol also has been investigated in the prevention of postpartum hemorrhage, using either the oral or rectal route of administration, and compared with placebo or other oxytocics. Results of most of these studies show a trend toward less postpartum hemorrhage with misoprostol, suggesting that it might be effective for this indication without causing serious side effects. These studies, however, failed to reveal a significant statistical difference regarding blood loss. Recent studies indicated misoprostol is comparable to standard oxytocics. Some experts argue that failure when the rectal route was used probably was due to a pharmacokinetic problem, since rate of absorption of misoprostol from the rectum is yet to be determined. They suggest that further research on the pharmacokinetic properties and transmucosal absorption of misoprostol is warranted.
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