Carac - Clinical Pharmacology
There is evidence that the metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid. In this manner, fluorouracil interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA). Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency that provokes unbalanced growth and death of the cell. The effects of DNA and RNA deprivation are most marked on those cells that grow more rapidly and take up fluorouracil at a more rapid rate. The contribution to efficacy or safety of individual components of the vehicle has not been established.
- Carac Information for Consumers
- Carac Information for Healthcare Professionals (includes dosage details)
- Side Effects of Carac (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 13 Oct 2009 • 1 answer
Posted 25 Dec 2009 • 2 answers
Posted 5 Jan 2010 • 1 answer
Posted 6 May 2010 • 1 answer
Posted 26 Mar 2011 • 1 answer