This is his 2nd attempt to stay on this dosage, he got cold after 3 weeks last time & suddenly went downhill, experiencing several of the serious side effects, I have my doubts as to whether the benefits if any,outweigh the the side effects, especially if he is to take these long-term. He is 59 yrs old, diagnosed with Reactive Arthitis - June 2010, healthy (pre- this illness) and average weight for his height.