Seems like I have to take atleast 2 of the 10/325's and still do not get the same relief as the 10/650. The pharmacy say's that they are the exat same strengh but I have been on the Endoset 10/650's for 5 years and there is a big differince in the way they affect me and the price. Seems like the 10/325's are weeker and they are about 15.00 more than the Endoset 10/650