The difference is their reaction times. Humulin R is short acting insulin, regular and it begins to work within 30 minutes of administering it, peaks at 2.5 to 5 hours, and lasts up to 6 hours. Humulin N is intermediate acting insulin in an isophane suspension-it begins working 1.5 to 4 hours after administering it, peaks 4-12 hours, and can last up to 24 hours in the body. Hope this helps.
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