Absorption from an oral dose is in the upper GI tract. Plasma level increase is dose related up to 50 mg orally and nonlinearly above that dose. After an oral dose, the time to C max is 0.5 to 2 h. Compared with IV administration, oral bioavailability is 0.6%. When coadministered with food, bioavailability may be decreased 90%.
Rapidly binds to bone or is excreted in the urine. Vd is at least 90 L. The amount removed from circulation via bone is estimated to be 40% to 50%.
No evidence of metabolism.
Cl is 84 to 160 mL/min. The portion not removed from the circulation via bone absorption (approximately 50% to 60% of absorbed dose) is eliminated unchanged by the kidney. Unabsorbed drug is eliminated unchanged in the feces.
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