the reviews seem to be the same for each one... just wondering how to know which one to try when I don't know the real differences.
What is the actual difference between all of these depression drugs?
Added 1 Aug 2011:
I took Wellbutrin for years with good results, but went off of it just to see if I still needed something. I do....so I tried Cymbalta since I have fibromyalgia, hated the fog it put me in. Now my Dr. asked if I want Prozac and ended up giving me a Rx for Zoloft. I haven't filled it yet, because I'm wondering if I should just go back to Wellbutrin. So...how are they all different? Why do some increase weight? I can't afford to gain any weight and I don't want to grind my teeth!!
I'm not an expert but: they all help, but I think that the difference between drugs is HOW they work on your symptoms, the mechanism (sort of like how different antibiotics work better for different infections... ) and how they work for you. My cousin does better with Prozac which didn't work for me, I do well on Wellbutrin XL and she can't tolerate it. Unfortunately of seems to be a bit of a trial and error thing, but sometimes talking with others and seeing what helps them will help make a decision easier.
There are different types of antidepressants depending on the neurotransmitter it effects. Neurotransmitters are the brain chemicals that send messages around the brain. Anyway, there are like 5 different type antidepressants: serotonin reuptake inhibitors (SSRIs), serotonin/ norepinephrine reuptake inhibitors (SNRIs), dopamine/norepinephrine reuptake inhibitors (DNRIs), tricyclics and monoamine oxidase inhibitors (MAOIs). Each acts a little differently in the brain. Unfortunately the doctor can not tell for sure which chemicals maybe imbalanced in your brain so it is a trial and error sort of deal. The Wellbutrin is a DNRI, the Cymbalta is a SNRI and the Prozac is a SSRI. So you are looking at each one acting slightly different than the other. You just have to try one and see how it works, give it a month, then if it doesn't work, try another. I wish it was one size fits all, but it isn't.
Nice thing about Wellbutrin is you can take it along with another antidperessant and not have ill effects. I take Wellbutrin along with Pristiq, an SNRI, with great results. You might try going back on the Wellbutrin then if need be add in another from either the SSRI category or from the SNRI category. Zoloft and Lexapro and quite popular SSRIs along with Prozac.
If I don't have you completely confused, like I said it is a trial and error ordeal to find the right combo, but once you do it is worth the effort.
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