Interactions between your selected drugs
alprazolam ↔ isosorbide dinitrate
Applies to: Xanax (alprazolam), isosorbide dinitrate
MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
MANAGEMENT: Caution is advised during coadministration of these agents. Close monitoring for development of hypotension is recommended. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
Other drugs that your selected drugs interact with
isosorbide dinitrate interacts with more than 100 other drugs.
Xanax (alprazolam) interacts with more than 300 other drugs.
Interactions between your selected drugs and food
alprazolam ↔ food
Applies to: Xanax (alprazolam)
GENERALLY AVOID: The pharmacologic activity of oral midazolam, triazolam, and alprazolam may be increased if taken after drinking grapefruit juice. The proposed mechanism is CYP450 3A4 enzyme inhibition.
MANAGEMENT: The manufacturer recommends that grapefruit juice should not be taken with oral midazolam. Patients taking triazolam or alprazolam should be monitored for excessive sedation. Alternatively, the patient could consume orange juice which does not interact with these drugs.
Dear Marcia... what Maso says is true and extremely thorough... this is how our dear Maso is... very thorough... thank you Maso!!! You should take into consideration everything that he has written.
From a practical perspective I think it would be fine for you to take the two medicines. Yes, Isordil is a vasodilator and will lower the blood pressure. This is a desirable effect along with the improvement of your coronary circulation.
You should monitor your blood pressure. But with low dose Xanax, say .25-.5 mg, I think it should be perfectly fine and acceptable to take Xanax while also on Isordil or isorsobide, generic name. I would use the Xanax sparingly only in times when you really need it for anxiety or at night to help u to sleep.
Good luck and stay well my friend...
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