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What enzymes metabolize Phenazopyridine and cipro. Does the the CYP2D6 play a part in the metaboliz?

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suzanne66 28 Apr 2010

The full pharmacokinetic properties of phenazopyridine have not been determined. Phenazopyridine metabolism is probably hepatic; also in other body tissues.Phenazopyridine is rapidly excreted by the kidneys, 65% as unchanged drug and metabolites.

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"... Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged Ciprofloxacin. Ciprofloxacin is an inhibitor of human cytochrome P450 1A2 (CYP1A2) mediated metabolism. Coadministration of Ciprofloxacin with other drugs primarily metabolized by CYP1A2 results in increased plasma concentrations of these drugs and could lead to clinically significant adverse events of the coadministered drug " free discount card

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