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What effect will eating grapefruit have on a person taking avodart?

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Rajive Goel 21 May 2010

Effects of Avodart (Dutasteride)

Cytochrome P-450 is a group of enzymes located throughout the body, with the largest amount found in the liver and the intestinal walls. This family of enzymes is responsible for making chemical reactions needed to breakdown many different compounds, from food to drugs. CYP3A4 is the most abundant member of the enzyme family. It is responsible for breaking down approximately 60% of the drugs taken.

When grapefruit or grapefruit juice is consumed, a compound within the grapefruit disrupts the CYP3A4 enzyme’s ability to metabolize a drug. If a drug is not adequately metabolized, higher levels of the drug may enter the bloodstream, which can lead to a potentially dangerous situation. These interactions have been observed within a few hours after consuming grapefruit and may last for up to 24 hours. As little as eight ounces (237 milliliters) can have an effect on the metabolism of some drugs.

However, please check it with your doc./pharmacist who has prescribed the med, hope this helps?

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