I have been bipolar since I was in my early teens and have been through literally almost every medication on the market. The best combination I have been on is 900mg of Lithium, 400mg of Lamictal, 10mg of Zyprexa, and 3mg of Klonopin. I also have a prescription for marijuana. I use the marijuana to go to sleep and stay asleep. It works much better than any sleeping pill or old tricyclic antidepressant like Elevil. I have not had a major depressive episode since 2005 which lasted 5 weeks. I lost 35 pounds those 5 weeks and overdosed on Ambien. I have had a few minor depressive episodes and some - mostly manageable hypo-mania, but that comes with the disease - I can handle that. Oh, I also take Lexapro for my OCD. It really works for me! Without the Lexapro my OCD consumes me.