I was on 5mg glyburide 2xdaily and 500mg metformin 2-3x daily. My A1c was 8-8.5. My Dr. added 100 januvia. Afterwards my sugar were much lower so I cut the am glyburide to 2.5, still too low... e.g. fasting sugars 4.4-5.5 (cut more than in half). Regards, jsf