A family member has had a lot of muscle pain since taking Azilect for Parkinson's relief in additon to Darvocet N-100 for pain management; I have also read the side effects can be life threatening. I've been trying to find out exactly what the the side effects of the two drugs interacting causes; they have since stopped taking the Azilect. Thank you for your help.
I HAVE DONE A DRUG INTERACTIONS CHECKERS ON THIS SITE AND WITH THE INFO YOU GAVE ON YOUR QUESTION THIS IS WHAT CAME UP.
I AM NOT A DOCTOR.
IF YOU QUESTIONS, CONTACT YOUR DOCTOR ... OK
Interactions between your selected drugs
propoxyphene ↔ rasagiline
Applies to: Darvocet-N 100 (acetaminophen/propoxyphene), Azilect (rasagiline)
CONTRAINDICATED: The coadministration of narcotic analgesics and monoamine oxidase inhibitors (MAOIs) may rarely result in hypotension, respiratory depression, or coma. The mechanism is unknown but may be related to additive CNS and respiratory depressant effects. Rare case reports of severe hypotensive reactions have included propoxyphene (with multiple medications), morphine, and methadone, although others have reported the safe use of MAOIs with narcotic analgesics including methadone and morphine.
MANAGEMENT: Some manufacturers consider the administration of narcotics and MAOIs within 2 weeks of each other to be contraindicated. However, morphine has been safely used in MAOI patients who previously had an adverse reaction with meperidine and is generally suggested as an alternative to meperidine in anesthesia, as long as vital signs are closely monitored. Other recommendations include giving patients small initial test doses of narcotics and monitoring vital signs for adverse reactions.
Other drugs that your selected drugs interact with
* Azilect (rasagiline) interacts with more than 200 other drugs.
* Darvocet-N 100 (acetaminophen/propoxyphene) interacts with more than 400 other drugs.
- Azilect Information for Consumers
- Azilect Information for Healthcare Professionals (includes dosage details)
- Side Effects of Azilect (detailed)
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