It just depends on what condition you are treating.
Pletal and Trental work differently and can be used for different conditions.
Pletal (cilostazol) widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.
Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.
Trental (pentoxifylline) changes the shape of red blood cells in your blood. This makes it easier for these blood cells to fit into small arteries (blood vessels).
Pentoxifylline is used to improve blood flow. Improved blood flow helps to reduce leg cramps and other symptoms of vascular disease (disease related to veins and arteries).
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