My mother who is 84 has been having problems with pain and swelling in both legs for about 8 months. She has been to numerous doctors. The many tests that she has been through has not turned up any answers to this problem. Could it be a drug or drug interaction? She takes blood pressure medicine, synthroid, tramadol, and amitriptyline. If it is not a drug or drug interaction, could it be some sort of inflammatory arthritis? She has not been diagnosed with inflammatory arthritis but should be our next step. If it is due to arthritis is there a medication she can take to relieve the symptoms in her legs?