Hi friends. I was recently diagnosed with Major Depressive Disorder. I have been on Celexa 20-30 mgs for a year, and am currently sitting at 20 mgs while being weaned off. I started Wellbutrin XL 150 mgs about three weeks ago, and have not had a good night's sleep since then. Melatonin, even at high doses, does not help me sleep. I have also been more anxious/irritable. Today, I took my first dose of Wellbutrin at 300 mgs at the advice of my psychiatrist. I'm an anxious mess, and all I can do is lay on the couch while feeling like I need to go run around in circles, but can't I get off of the couch. Should the side effects still be this bad at 3 weeks use?