... about 14 years
Yes , decreased memory.
The Australian Adverse Drug Reaction Advisory Committee reported that 285 of the 780 reports it received in association with bupropion (the active ingredient contained in Wellbutrin SR) through mid-May 2001 involved psychological disturbances.
Two cases of tactile hallucinations ("bugs crawling over skin") have been reported in association with bupropion extended-release (200 mg twice daily) therapy. In both cases the symptoms abated following a reduction in the total daily dose of bupropion (300 mg daily).
Insomnia may also be dose-dependent. In a dose response clinical study for smoking cessation, 29% of patients receiving bupropion 150 mg/day versus 35% of those receiving 300 mg/day reported insomnia. Insomnia may be minimized by reducing the dosage or avoiding administration at bedtime.[Ref]
Very common (10% or more): Insomnia
**Common (1% to 10%): Abnormal dreams, agitation, anxiety, confusion, ***decreased memory***, delusions, depression, disturbed concentration, euphoria, hallucinations, hostility, impaired sleep quality, irritability, mania/hypomania, nervousness, thinking abnormality
Uncommon (0.1% to 1%): Bruxism, depersonalization, dysphoria, emotional lability, formal thought disorder, frigidity, mood instability, paranoia, psychosis, suicidal ideation
Rare (less than 0.1%): Derealization, dysarthria, impaired attention, suicidal ideation
Very rare (0.01% to 0.1%): Aggression, paranoid ideation, restlessness
Frequency not reported: Completed suicide, delirium, manic reaction, suicide attempt[Ref]"
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