I have Welchol 625MG. Prescribed for 2x a day. That caused constipation. If I take 1 pill, I don't have a movement until the 2nd day and it is explosive and burns. I have IBS and my gallbladder removed. I don't take it unless I've had several diarrhea episodes in one day. When OTC anti-diarrhea meds don't work Welchol is my pill of last resort.