One study in which 150 patients received the sustained released form of bupropion (the active ingredient contained in Wellbutrin) reported the incidence of orgasm dysfunction at 8% in patients receiving a 300 mg daily dose and 10% in patients receiving a 400 mg daily dose.
Among antidepressants, bupropion may be associated with the lowest incidence of sexual dysfunction (i.e., impotence, abnormal ejaculation, changes in libido).[Ref]
Common (1% to 10%): Decrease in sexual function, dysmenorrhea, increased/decreased libido, menstrual complaints, nocturia, urinary frequency, urinary tract infection, urinary urgency, vaginal hemorrhage
Uncommon (0.1% to 1%): Impotence, polyuria, prostate disorder, testicular swelling, vaginal irritation
Rare (less than 0.1%): Enuresis, urinary incontinence
Frequency not reported: Abnormal ejaculation, cystitis, dyspareunia, dysuria, gynecomastia, menopause, painful erection, salpingitis, urinary retention, vaginitis
Postmarketing reports: Prostate disorder, urinary tract disorder
- Wellbutrin Information for Consumers
- Wellbutrin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Wellbutrin (detailed)
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