I have Bipolar Type II and have been on Seroquel (200 mg initially then 200 mg XR) and Lamictal (200 mg twice daily) for years with adjunct anti-depressants added as needed for break through depression as well as clonazepam as needed for anxiety. As I understand it, I'm on a very low dose of Seroquel but the weight gain, drowsiness, and hunger are UNBEARABLE! Thirty two pounds of weight in three years. The drowsiness is even negatively affecting my marriage. My husband, despite his support for my disorder, does get frustrated by the 10 hours sleep/night PLUS a nap (or two) daily. Has the transition from Seroquel to Latuda gone well for most? From what I've read (and heard from another patient) this is a much preferable drug.