Hi, Within approx two weeks of my signifigant other having had his 3rd injection he became terribly ill -- joints all seemed to?feel like they "dried up" in shoulders, groin, hips, hands. He can't sleep, has lost his muscle tone and is on large amounts of prenazone just to function. We've been to Rheumatology dr, infectious disease etc etc with 30+ blood workups. No one can find anything but I feel there is some connection to the Orthovisc shot. Ironically, his knee is better but his body is falling apart. Has anyone ever heard of something like this happening? We are desperate - he is in incredible pain and doctors just keep sending us in circles.