i also take roxicodone 15mg 4x day. they don't seem to work like they use to. i have been on these meds for 10 years. i had spinal fusion reconstruction for isthmic spondylolisthesis high grade. my life has changed so much since. i have been going to the same doctor from the beginning, i've tried telling him that the meds just are not working very well anymore but he acts like he scared to increase the dose with all the misuse and media about these meds. i have been researching opana as an option for change. i go see him next week and plan on telling him something has got to change so i wanted to have all the info i can when i discuss this with him. any info would be helpful.