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Vilazodone - what is the nursing action for those taking Viibryl medicine drugs?

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DzooBaby 13 Jul 2011

I'm not sure what you are looking for but see if any of this info helps:
Black Box Warnings
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants for major depressive disorder and other psychiatric disorders; not approved for use in pediatric patients

Contraindications
Hypersensitivity

MAOIs: Do not administer concomitantly or within 14 days of MAO inhibitors because of serious and sometimes fatal drug interactions may occur with serotonergic drugs, with symptoms including tremor, myoclonus, diaphoresis, nausea, vomiting, flushing, dizziness, hyperthermia with features resembling neuroleptic malignant syndrome, seizures, rigidity, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma

Cautions
May precipitate mixed/manic episode if initiated for bipolar disorder

May cause serotonin syndrome or neuroleptic malignant syndrome-like reactions including agitation, hallucinations, coma, autonomic instability (eg, tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (eg, hyperreflexia, incoordination), and/or gastrointestinal symptoms (eg, nausea, vomiting, diarrhea)

Has not been systematically evaluated in patients with seizure disorders (caution advised)

Serotonin reuptake inhibition may increase risk of bleeding (caution with drugs that inhibit platelets or coagulation)

Decrease dose gradually when discontinuing to avoid dysphoric mood, irritability, insomnia, agitation, and confusion

CYP3A4 (major substrate); CYP2C19 (minor substrate, minor inhibitor, minor inducer); CYP2D6 (minor substrate, minor inhibitor); CYP2C8 (moderate inhibitor); increased plasma concentration (by 50%) observed when coadministered with strong CYP3A4 inhibitors (eg, ketoconazole)

Highly bound to plasma proteins (administration to patient taking another drug that is highly protein bound may increase free concentrations of the other drug)

Hyponatremia has been reported with other SSRIs, and SNRIs; common adverse effects include diarrhea, nausea, xerostomia, dizziness, and insomnia; can occur in association with syndrome of inappropriate antidiuretic hormone secretion (SIADH)

MAOIs (see Contraindications)

Coadministration with 5HT receptor agonist (ie, triptan), other serotonergic drugs (eg, SSRIs, SNRIs, buspirone, tramadol), or antidopaminergic drugs may increase risk for serotonin syndrome

Concomitant use with serotonin precursors (eg, tryptophan) not recommended

Serotonin reuptake inhibition may increase risk of bleeding (caution when coadministered with aspirin, NSAIDs, warfarin, and other anticoagulants)

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