... flaking off and my feet and knees are painful. I have had a lot of tests with no diagnosis being made. I noticed one list of possible side effects mentioned a similar condition. I have been on Venoafaxine for several years after trying many other meds for depression, this is by far the most effective for me. This condition started about 12 months ago when I was hospitalised to increase my dosage. Has anyone else heard of this, I don't want to be weaned off it but I can't stay in bed forever with my legs elevated