I cant find the answer to this. Zyban with moclobemide is considered not safe. I hope I can take this newer anti smoking aid!
Varenicline - I take 300mg Moclobemide daily. Is it safe for me to also take chantix to help me stop
- 8 Feb 2011 by si999
- 26 Nov 2012
- chantix, zyban, smoking, smoking cessation, varenicline
Moclobemide is a monoamine oxidase inhibitor.
I have used the monoamine oxidase inhibitor available in the United States (Selegiline) to do an interaction check, as shown in the link below. Moclobemide is not an approved medicine in the United States.
It shows that there are no known interactions between selegiline and Chantix (varenicline). I would say it would be safe to say that it would be okay to take Chantix with moclobemide. BUT please get your doctor to check this out as well.
Perhaps your local pharmacy has an interaction database, including moclobemide and they could check out if there is an interaction between Chantix and moclobemide. All the best.
Moclobemide is a Reversible Inhibitor of Monoamine Oxidase A. (RIMA) Meaning it is safer (when it comes to dietary monoamine intake) than any old MAOI. In theory, varenicline (chantix) and moclobemide (aurorix, manerix) shouldn't interact in any dangerous way.
In fact, I would propose that being on moclobemide while taking varenicline would in fact improve your chances of successfully quitting smoking. This is because it (moclobemide) exaggerates the pleasurable, or rewarding effects of the α4β2 nicotinic acetylcholine receptor (nAChR) partial agonistic effects of varenicline. It achieves this by slowing the degradation of dopamine by inhibiting one of the chief enzymes that mediates its degradation. (Monoamine oxidase A) It would also exaggerate its (varenicline) stimulating effects by increasing both the activity of dopamine and norepinephrine.
There is another thing that moclobemide does that might be beneficial for you while you're trying to cease smoking. This is because it treats major depression. (MD) Patients with untreated MD have been found to have twice to three times the difficulty in quitting smoking and 50-60% of patients with MD also smoke as opposed to around 20-25% of the unaffected population. (Breslau, N., Johnson, E. O., 2000)
1.) Breslau, N., Johnson, E. O. (2000). Predicting smoking cessation and major depression in nicotine-dependent smokers. American Journal of Public Health. doi: 10.2105/AJPH.90.7.1122
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