My wife was given DEPAKOTE for mania.It was amazing how she was transformed from someone who was swinging on the chandelier to a perfectly normal human being in a very short space of time.It is without doubt a wonderdrug. Only problem is, she has recently_ after being on it for 6 months_started bleeding from her rectum. We stopped the Depakote and within a couple of days the bleeding stopped.When we were forced to continue with the drug, the bleeding started again.Her psychiatrist stopped it altogether and once again the bleeding also stopped. She has had Endoscomy on her bowel and lower colon which revealed a large area of inflammation. Could the Depakote be the cause of it or do we need to look elsewhere.