The majority of the body's serotonin, between 80-90%, can be found in the gastrointestinal tract. Serotonin that is used inside the brain must be produced within it. It is thought that serotonin can affect mood and social behavior, appetite and digestion, sleep, memory and sexual desire and function.
SSRIs work by enhancing the function of nerve cells in the brain that regulate emotion. Information is communicated between your brain cells with signals. The chemical messengers that deliver these signals are called neurotransmitters. Serotonin is one type of neurotransmitter.
When these brain cells (called neurons) send signals to one another, they release a little bit of a neurotransmitter so that the message can be delivered. They then have to take back the neurotransmitter they released so they can send the next message. This process of replacing the neurotransmitter is called “reuptake.”
If you’re struggling with depression, the areas of your brain that regulate mood and send messages using serotonin might not function properly. SSRIs help make more serotonin available by blocking the reuptake process. This allows serotonin to build up between neurons so messages can be sent correctly. They’re called “selective” serotonin reuptake inhibitors because they specifically target serotonin.
Source: Wed MD
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- Side Effects of Trintellix (detailed)
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