I'm 61; started 2 days ago at 2.5, now 5 mg on third day because of no physical side effects Yet except racing and loud heartbeat. Today, however, I feel even more dead, if that's possible. Tough to concentrate on my work, not sleeping, no interest in doing my workouts (which is Really a huge sign in my case), no interest in eating and food does not taste good, don't want to talk to anyone. It was already like this before, but today is suddenly crazy worse. No other exacerbating factors that I can think of that would complicate things. Ah -- I took 3/4 of a 5 mg valium to try to sleep last night. Hope that provides enough introductory material for a respondent.
Can Trintellix "cause" further depression?
- Asked
- 10 Jan 2018 by KL42
- Updated
- 23 Feb 2018
- Topics
- depression, major depressive disorder, side effect, trintellix
Responses (3)
Hi, KL! Increased depression/anxiety/depersonalization/inappetance/sleep disturbances commonly occur when first starting an antidepressant, but the good news is that they resolve after just a few days to a week or so. These effects should subside a little each day as your metabolism adjusts to the medication.
You should, however, be sure to let your doctor know how you're doing as you are on a very low starting dose and you may need to stay on the 2.5mg dose until these side effects resolve.
Best regards, Wildcat
Ahh, thank you So much! That's amazing to hear, yike. I've avoided anti-depressants my entire life, and it's definitely difficult to see myself "giving in" to them Now. That downer self-incrimination surely doesn't help this whole process, eh...
Again, thank you.
Sorry to hear about your situation ~ my family still lives in CA and you guys have really gotten hammered this year!
As for the meds, well, I understand to a degree but something sent you to the doctor when your life was spiraling downwards. Compared to living like that for much longer, a happy and healthy life on meds doesn't look so bad.
Personally, I've been on medication since my teen years ~ and I wouldn't be here now if I hadn't been.
I wish you good luck and a very good New Year. Stay safe... and dry! WC
Thank you, Wildcat. I appreciate your words and input with Such gratitude. xoxo
Hi, that is a very good question and I am starting to think that it just may be what I am dealing with too. I am 62 and I have been taking 10mg of Trintellix since November and I feel terrible. I have no motivation for anything. I don’t want to go to church,(very very strange for me), I no longer enjoy meeting with a group of ladies to do crafts that I thoroughly enjoyed before Trintellix. Like you I don’t want to eat, I just don’t want to do anything. I saw my psychiatrist last week and he upped my dose to 15mg and if anything I feel worse. I have to wait for 3 months to see him again. Not sure if my response helps you but your question opened my eyes to this drug.
Ahhh, that's just cr*p. I am So sorry. I mean, if I were the only one feeling like this, it would almost be better; but right, I know I'm not. Thank you immensely for your input and descriptions, Brat62 (great name). I'll bet you feel pretty bloody alone, not seeing the doc again for 3 months?? Actually -- I just received this notification that you'd responded, yet it says you answered on January 10. I'm sorry for not getting back earlier; and if things have changed for you, or are looking up, or you quit, or anything else, I'd love to hear back from you. All the very best and peace to you.
Hi KL42,
I posted my response yesterday when I read your comment so I am trying to talk to my doctor today to see if he can switch me to something different.
Thanks for your reply!

Further Information
- Trintellix Information for Consumers
- Trintellix Information for Healthcare Professionals (includes dosage details)
- Side Effects of Trintellix (detailed)
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Thank you So much. (I actually did call my doc this morning, but I live in Santa Barbara, CA, and the mudslides/flooding/fires affected his ability to even communicate with and/or to see patients. It's pretty messed up around here right now, haaa. I tried to leave a message, though... thank you again!