I am currently treated for high blood pressure with Lisinopril 20 mg 2 x day, Metoprolol 100 mg 2 x day, and Indapamide 1.25 1 x per day. I have developed either an accute or possibly chronic anal fissure that has not responded to a high fiber diet, analgesic or cortisone ointments. My doctor has prescribed a topical nifedipine for the treatment of the fissure. I've read that it is very effective however my concern is that my blood pressure will drop too low. It is already low due to a recent change from Hydralazine 50 mg 2 x per day replaced with the Lisinopril 20 mg 2 x day, which dropped my pressure from a routine reading range of 160/70 to now 100/60. It's possible that even w/out the nifedipine, the change from Hydralazine to Lisinopril I may be over-medicated resulting in a blood pressure that is too low.