I have been diagnosed with severe OCD and generalized anxiety disorder, and have been suffering with extreme symptoms for the past two years. Throughout this period, I have been regularly seeing a psychologist and working on CBT therapies. It was quickly evident that medication was necessary, as my symptoms are quite severe. Throughout this period of pharmacological treatment, I tried a variety of medications including SSRIs, and SNRI, benzodiazepines, an anti-psychotic, and a tricyclic. Each of these medications worsened the severity of my OCD (some more than others) significantly, such that I have been unable to remain on most of these medications for a very lengthy duration; the medications also seem to cause extreme fatigue. I am also very sensitive to most of the medications I have tried, and usually start at a dosage about 1/5th-1/10th of what is normally prescribed. For instance, I was on Zoloft for 4 months (I could tolerate this moderately well at a low dosage) at a dosage of 5 mg/day. I tried for one 4 week-period to increase to 10 mg/day, but was totally non-functional for this period. If I increase the dosage too much, the OCD becomes unbearable, and I am often debilitated by fatigue. I apologize for the lengthy description, but feel that I am running out of treatment options. I am a student and have been on medical leave for 1.5 years, and am so eager to return to my studies. I appreciate any advice or experience that anyone is able to offer. Thank you.