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Trazodone - what is the correct dossage for treating depression?

Responses (2)

LaurieShay 5 Dec 2011

Hi jay,

The literature states the following for trazadone and depression:

Usual Adult Dose for Depression

Immediate-release tablets:
Initial dose: 150 mg per day in divided doses.
Maintenance dose: May be increased by 50 mg per day every 3 to 4 days. The maximum dose for outpatients usually should not exceed 400 mg per day in divided doses. Inpatients may be given up to but not in excess of 600 mg per day in divided doses.
Trazodone should be taken shortly after a meal or light snack.

Extended-release tablets:
Recommended starting dose: 150 mg once daily
Maintenance dose: The dose may be increased by 75 mg/day every three days (for example, start 225 mg on day 4 of therapy).
Maximum daily dose: 375 mg
Trazodone extended-release tablets should be taken orally at the same time every day, in the late evening preferably at bedtime, on an empty stomach. Once an adequate response has been achieved, dosage may be gradually reduced, with subsequent adjustment depending on therapeutic response.

Hope this helps,


Anonymous 6 Dec 2011

Hello jay202. Just to add what Laurie said, most people seem to do well on between 200 and 400mg. Usually always taken before or at bedtime since its so sedateing. Best of wishes to you, free discount card

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