My Mother is 76. She has COPD/emphysema and coughs constantly. She is also a heart patient on Coreg and Cardura (5 bypasses). She also has some arthritis. Her pulmonologist prescribed 50 mg Tramadol twice a day,Zoloft (for depression) and 5 mg Prednisone. She alleges this helped reduce the cough. She has since had hip surgery and was further prescribed (by another doctor) Zanax (anxiety to cough). She is now home recovering and not in pain any longer. I find she if confused, forgetful, sounds drugged and sleeps too much. Is there too much interaction with Tramadol/Zanax and/or Zoloft?