I've had kidney stones once before, years ago. How likely is it that Topamax would cause them? I'd much rather take it than Depakote but I really really don't want kidney stones again.
Topamax and Kidney Stones?
- 22 Sep 2011 by shiftinshapes
- 23 September 2011
- topamax, nephrolithiasis, migraine prevention
Added 23 Sep 2011:
ETA: I think I phrased that badly. What I'm really interested in knowing is if I'm more likely to get kidney stones on Topamax because I've had them before.
"Renal side effects including kidney stones (1.3% to 1.5%) and renal tubular acidosis have been reported."
Side Effects by Body System - for Healthcare Professionals
General side effects including fatigue, fever, and malaise have been reported to occur frequently. Oligohidrosis, pain, chest pain, and hyperthermia have also been reported.
The majority of cognitive-related adverse events were mild to moderate in severity and frequently occurred in isolation. Rapid titration rate and higher initial doses were associated with higher incidences of cognitive-related adverse events.
Nervous system side effects have been common and have included somnolence, dizziness (greater than 25%), ataxia, speech disorders, psychomotor slowing, hypokinesia, vertigo, grand mal seizures, diplopia, nystagmus, tinnitus, and paresthesias. These nervous system adverse reactions do not appear to be dose-related. Dose-related adverse effects have included fatigue (frequently), nervousness, difficulty with concentration or attention, confusion, psychomotor slowing, difficulty with concentration/attention, difficulty with memory, speech, or language problems (particularly word finding difficulties), and tremor. Headache, vertigo, sensory disturbance, and aggravated migraine have also been reported. A case has been reported of cerebrospinal fluid acidosis associated with hyperventilation that was probably caused by topiramate.
Hepatic side effects including hepatic failure (sometimes fatal) and hepatitis have been reported.
The primary treatment of cases of secondary angle closure glaucoma cause by topiramate is discontinuation of the drug.
Ocular side effects including cases of secondary angle closure glaucoma characterized by ocular pain, acute myopia, abnormal accommodation, and increased intraocular pressure have been reported. Maculopathy has also been reported.
Gastrointestinal side effects include diarrhea, vomiting, pancreatitis, gastroenteritis, constipation, gastroesophageal reflux, tooth disorder, and flatulence have been reported. Tongue edema has been reported rarely.
Cardiovascular side effects including palpitations have been reported frequently. Hypertension and hypotension have been reported infrequently.
Hematologic side effects including anemia and epistaxis have been a reported frequently.
Metabolic side effects have included metabolic acidosis, dehydration, diabetes mellitus, and weight increase.
Musculoskeletal side effects including arthralgia, myalgia, and muscle weakness have been reported. A case of hemiparesis has also been reported.
Psychiatric side effects including insomnia, personality disorder, impotence, hallucination, euphoria, psychosis, decreased libido, anxiety, depression, mood problems, and suicide attempts have been reported. Two cases of panic attacks have also been reported.
Depression and mood problems were dose related.
Genitourinary side effects in the female frequently have included intermenstrual bleeding, leukorrhea, menorrhagia, vaginitis, and amenorrhea. Urinary tract infections, micturition frequency, urinary incontinence, dysuria, and renal calculus have also been reported frequently. Cases of reversible anorgasmia have also been reported. Kidney stones (1.5%) have occurred more frequently in men.
Respiratory side effects including pulmonary embolism, coughing, pneumonia, asthma, and bronchitis have been reported.
Dermatologic side effects including bullous skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), pemphigus, acne, rash, and alopecia have been reported. Pruritus has been reported rarely.
Other side effects including taste perversion have been reported frequently. Headaches have also been reported to occur.
Renal side effects including kidney stones (1.3% to 1.5%) and renal tubular acidosis have been reported.
Hypersensitivity side effects including allergic reaction have been reported.
Immunologic side effects have been reported including infection and genital moniliasis.
- Topamax Information for Consumers
- Topamax Information for Healthcare Professionals (includes dosage details)
- Side Effects of Topamax (detailed)
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