Imipenem & Cilstatin IV
TIENAM is generally well tolerated. In controlled clinical studies, TIENAM was found to be tolerated as well as cefazolin, cephalothin, and cefotaxime. Side effects rarely require cessation of therapy and are generally mild and transient; serious side effects are rare.
Erythema, local pain and induration, thrombophlebitis.
Rash, pruritus, urticaria, erythema multiforme, Stevens-Johnson syndrome, angioedema, toxic epidermal necrolysis (rarely), exfoliative dermatitis (rarely), candidiasis, fever including drug fever, anaphylactic reactions.
Nausea, vomiting, diarrhea, staining of teeth and/or tongue. In common with virtually all other broad spectrum antibiotics, pseudomembranous colitis has been reported.
Eosinophilia, leukopenia, neutropenia, including agranulocytosis, thrombocytopenia, thrombocytosis, and decreased hemoglobin, pancytopenia and prolonged prothrombin time have been reported. A positive direct Coombs' test may develop in some individuals.
Increases in serum transaminases, bilirubin and/or serum alkaline phosphatase; hepatic failure (rarely), hepatitis (rarely) and fulminant hepatitis (very rarely).
Oliguria/anuria, polyuria, acute renal failure (rarely). The role of TIENAM in changes in renal function is difficult to assess, since factors predisposing to pre-renal azotemia or to impaired renal function usually have been present.
Elevations in serum creatinine and blood urea nitrogen have been observed. Urine discoloration. This is harmless and should not be confused with hematuria.
NERVOUS SYSTEM /PSYCHIATRIC
As with other beta-lactam antibiotics, CNS side effects such as myoclonic activity, psychic disturbances, including hallucinations, confusional states, or seizures have been reported. Paresthesia, encephalopathy.
Hearing loss, taste perversion.
Drug-related nausea and/or vomiting appear to occur more frequently in granulocytopenic patients than in nongranulocytopenic patients treated with TIENAM I.V.
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