Skip to Content

Tienam side effect?

Responses (1)

Rajive Goel 5 Jun 2010

Imipenem & Cilstatin IV

TIENAM is generally well tolerated. In controlled clinical studies, TIENAM was found to be tolerated as well as cefazolin, cephalothin, and cefotaxime. Side effects rarely require cessation of therapy and are generally mild and transient; serious side effects are rare.

LOCAL REACTIONS
Erythema, local pain and induration, thrombophlebitis.

ALLERGIC REACTIONS/SKIN
Rash, pruritus, urticaria, erythema multiforme, Stevens-Johnson syndrome, angioedema, toxic epidermal necrolysis (rarely), exfoliative dermatitis (rarely), candidiasis, fever including drug fever, anaphylactic reactions.

GASTROINTESTINAL REACTIONS
Nausea, vomiting, diarrhea, staining of teeth and/or tongue. In common with virtually all other broad spectrum antibiotics, pseudomembranous colitis has been reported.

BLOOD
Eosinophilia, leukopenia, neutropenia, including agranulocytosis, thrombocytopenia, thrombocytosis, and decreased hemoglobin, pancytopenia and prolonged prothrombin time have been reported. A positive direct Coombs' test may develop in some individuals.

LIVER FUNCTION
Increases in serum transaminases, bilirubin and/or serum alkaline phosphatase; hepatic failure (rarely), hepatitis (rarely) and fulminant hepatitis (very rarely).

RENAL FUNCTION
Oliguria/anuria, polyuria, acute renal failure (rarely). The role of TIENAM in changes in renal function is difficult to assess, since factors predisposing to pre-renal azotemia or to impaired renal function usually have been present.
Elevations in serum creatinine and blood urea nitrogen have been observed. Urine discoloration. This is harmless and should not be confused with hematuria.

NERVOUS SYSTEM /PSYCHIATRIC
As with other beta-lactam antibiotics, CNS side effects such as myoclonic activity, psychic disturbances, including hallucinations, confusional states, or seizures have been reported. Paresthesia, encephalopathy.

SPECIAL SENSES
Hearing loss, taste perversion.

GRANULOCYTOPENIC PATIENTS
Drug-related nausea and/or vomiting appear to occur more frequently in granulocytopenic patients than in nongranulocytopenic patients treated with TIENAM I.V.

Hope this helps?

Drugs.com free discount card

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar Questions