I started out taking synthroid 75mcg. I have always been very active and you could not stop me from going. NOW, I hurt in joints, my mental awareness is very slow, I have gained LOTS of weight fast! I feel like a bus has ran over me. There are some days I cannot even get out of bed. I was always the happy go lucky person everyone wanted to be around. Now i am depressed,feel fat, no engery at all. I cry at the drop of a hat. Please tell me when I can expect to see a change? My blood test is off the chart TSH is 201.200 my T4 is low showing 0.14 Low... PLEASE give me some hope I will be me again???