I started on Nucynta IR 75mg 3x a day 2 years ago. Did great at first but became less effective over time. Last year my Dr. switched me to Nucynta ER 150mg 2x a day. I immediately started feeling sad. Now due to insurance I couldn't afford my prescription last week ( had a coupon that I always used to get it for $25. But cvs said even with the coupon it was $580, something about deductibles.). This is day 3 without it and I just want to lay on the floor and cry. I feel soooooo sad.