It's listed on the package not to use with certain drugs for depression.Although Zyban is not used for depression.It does contain bupropion HCI a drug that is used for depression.
Its probably not a good idea to take Alka Seltzer plus with Zyban because of a potential drug interaction with some of the ingredients.
For details see:https://www.drugs.com/interactions-check.php?drug_list=42-7323,440-205
Talk with your pharmacist - there will be something else you can safely take depending on your symptoms.
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