I recently upped my dosage to 400 mg of Seroquel, and I am also on 100 mg of Lamitical. I have been taking Seroquel for fours years now and It's worked like a charm. I have mixed other medications (antidepressants mainly) with Seroquel and the Seroquel never seemed to be the problem. I haven't been able to sleep more than 3 hours a night for the last two weeks. Although I am sleep deprived my mood is more stable than it's ever been. But I really need sleep, has anyone else experience this? Or any suggestions on getting sleep? X