The interaction is minor which means:
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Interactions between your selected drugs
clozapine ↔ divalproex sodium
Applies to: clozapine, Depakote (divalproex sodium)
Several reports have suggested that valproate may slightly increase serum clozapine levels and levels of clozapine metabolites. Increased sedation and functional impairment may result. The mechanism of this interaction is unknown, as is its clinical significance. If clozapine and valproic acid or any of its derivatives must be used together, close observation for altered clozapine effect is recommended.
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Other drugs that your selected drugs interact with
clozapine interacts with more than 600 other drugs.
Depakote (divalproex sodium) interacts with more than 200 other drugs.
Interactions between your selected drugs and food
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
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