The best person to answer that question would be your doctor. I have been on just one sometimes... but do seem to do best with the two I am on now. They are Cardizem ER 360mg and Verapamil ER 240 mg. I know they are both calcium-channel blockers, but they are what seems to work best for me. I have asthma... and use to take a beta-blocker and my asthma doctor said it was causing a chronic cough and needed to be switched because they constrict the bronchials and make asthmatics worse in the long run. I do have supra-ventricular tachycardia also.
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